The Overcoming COVID-19 study seeks to track and characterize the development of complications in children and young adults as a result of exposure to the novel coronavirus, SARS-CoV-2, one such outcome being Multisystem Inflammatory Syndrome in Children (MIS-C). Through real-time surveillance and reporting, as well as prospective enrollment of study participants with collection of blood and respiratory samples, this study intends to understand the risk factors and outcomes of COVID-19 critical illness in the pediatric population, define complications in young individuals thought to be related to SARS-CoV-2, identify predictive markers of these complications, and characterize the development and maintenance of adaptive immunity.